Genetic diversity of Bm86 sequences in Rhipicephalus (Boophilus) microplus ticks from Mexico: analysis of haplotype distribution patterns

Artículo científico derivado de Tesis doctoral de Saúl Gabriel Martínez ArzateBackground: Ticks are a problem for cattle production mainly in tropical and subtropical regions, because they generate great economic losses. Acaricides and vaccines have been used to try to keep tick populations under control. This has been proven difficult given the resistance to acaricides and vaccines observed in ticks. Resistance to protein rBm86-based vaccines has been associated with the genetic diversity of Bm86 among the ectoparasite’s populations. So far, neither genetic diversity, nor spatial distribution of circulating Bm86 haplotypes, have been studied within the Mexican territory. Here, we explored the genetic diversity of 125 Bm86 cDNA gene sequences from R. microplus from 10 endemic areas of Mexico by analyzing haplotype distribution patterns to help in understanding the population genetic structure of Mexican ticks. Results: Our results showed an average nucleotide identity among the Mexican isolates of 98.3%, ranging from 91.1 to 100%. Divergence between the Mexican and Yeerongpilly (the Bm86 reference vaccine antigen) sequences ranged from 3.1 to 7.4%. Based on the geographic distribution of Bm86 haplotypes in Mexico, our results suggest gene flow occurrence within different regions of the Mexican territory, and even the USA. Conclusions: The polymorphism of Bm86 found in the populations included in this study, could account for the poor efficacy of the current Bm86 antigen based commercial vaccine in many regions of Mexico. Our data may contribute towards designing new, highly-specific, Bm86 antigen vaccine candidates against R. microplus circulating in Mexico.SIEAE UAEM FES

Responsabilidad Social y Ciudadanía: Una perspectiva desde la universidad y la administración pública

La importancia de los estudios sobre ciudadanía se vincula con la imperiosa necesidad de fortalecer la democracia en todos aquellos espacios donde se manifiesta, principalmente en países como México, donde la falta de credibilidad en las instituciones democráticas ha permeado a la sociedad.Los desafíos contemporáneos requieren nuevos ajustes en diversos sentidos; al interior de las organizaciones es necesario adecuar los mecanismos con que interactúan frente a la sociedad en la que se desarrollan. Es requisito indispensable que el grueso de las organizaciones sociales se vinculen de manera directa con los problemas globales y nacionales: cambio climático, guerras, exigencias democráticas, movimientos sociales, pobreza, desempleo, inestabilidades políticas etc., ello les exige que se asuman como parte del complejo social, donde sus acciones repercuten de forma directa o indirecta

The large area detector onboard the eXTP mission

The Large Area Detector (LAD) is the high-throughput, spectral-timing instrument onboard the eXTP mission, a flagship mission of the Chinese Academy of Sciences and the China National Space Administration, with a large European participation coordinated by Italy and Spain. The eXTP mission is currently performing its phase B study, with a target launch at the end-2027. The eXTP scientific payload includes four instruments (SFA, PFA, LAD and WFM) offering unprecedented simultaneous wide-band X-ray timing and polarimetry sensitivity. The LAD instrument is based on the design originally proposed for the LOFT mission. It envisages a deployed 3.2 m2 effective area in the 2-30 keV energy range, achieved through the technology of the large-area Silicon Drift Detectors - offering a spectral resolution of up to 200 eV FWHM at 6 keV - and of capillary plate collimators - limiting the field of view to about 1 degree. In this paper we will provide an overview of the LAD instrument design, its current status of development and anticipated performance

Arquitectura térmica de instrumentación científica para vuelos suborbitales

Se hace un análisis térmico por metodos analiticos y numéricos de los instrumentos PIXQUI y EUSO-BALLOO

Design, integration, and test of the scientific payloads on-board the HERMES constellation and the SpIRIT mission

HERMES (high energy rapid modular ensemble of satellites) is a space-borne mission based on a constellation of nano-satellites flying in a low-Earth orbit (LEO). The six 3U CubeSat buses host new miniaturized instruments hosting a hybrid silicon drift detector/GAGG:Ce scintillator photodetector system sensitive to x-rays and gamma-rays. HERMES will probe the temporal emission of bright high-energy transients such as gamma-ray bursts (GRBs), ensuring a fast transient localization (with arcmin-level accuracy) in a field of view of several steradians exploiting the triangulation technique. With a foreseen launch date in late 2023, HERMES transient monitoring represents a keystone capability to complement the next generation of gravitational wave experiments. Moreover, the HERMES constellation will operate in conjunction with the space industry responsive intelligent thermal (SpIRIT) 6U CubeSat, to be launched in early 2023. SpIRIT is an Australian-Italian mission for high-energy astrophysics that will carry in a sun-synchronous orbit (SSO) an actively cooled HERMES detector system payload. On behalf of the HERMES collaboration, in this paper we will illustrate the HERMES and SpIRIT payload design, integration and tests, highlighting the technical solutions adopted to allow a wide-energy-band and sensitive x-ray and gamma-ray detector to be accommodated in a 1U CubeSat volume

The wide field monitor onboard the Chinese-European x-ray mission eXTP

The eXTP (enhanced X-ray Timing and Polarimetry) mission is a major project of the Chinese Academy of Sciences (CAS), with a large involvement of Europe. The scientific payload of eXTP includes four instruments: the SFA (Spectroscopy Focusing Array) and the PFA (Polarimetry Focusing Array) - led by China - the LAD (Large Area Detector) and the WFM (Wide Field Monitor) - led by Europe (Italy and Spain). They offer a unique simultaneous wide-band X-ray timing and polarimetry sensitivity. The WFM is a wide field X-ray monitor instrument in the 2-50 keV energy range, consisting of an array of six coded mask cameras with a field of view of 180ºx90ºat an angular resolution of 5 arcmin and 4 silicon drift detectors in each camera. Its unprecedented combination of large field of view and imaging down to 2 keV will allow eXTP to make important discoveries of the variable and transient X-ray sky and is essential in detecting transient black holes, that are part of the primary science goals of eXTP, so that they can be promptly followed up with other instruments on eXTP and elsewhere

The HERMES-technologic and scientific pathfinder

HERMES-TP/SP (High Energy Rapid Modular Ensemble of Satellites Technologic and Scientific Pathfinder) is a constellation of six 3U nano-satellites hosting simple but innovative X-ray detectors, characterized by a large energy band and excellent temporal resolution, and thus optimized for the monitoring of Cosmic High Energy transients such as Gamma Ray Bursts and the electromagnetic counterparts of Gravitational Wave Events, and for the determination of their positions. The projects are funded by the Italian Ministry of University and Research and by the Italian Space Agency, and by the European Union's Horizon 2020 Research and Innovation Program under Grant Agreement No. 821896. HERMES-TP/SP is an in-orbit demonstration, that should be tested starting from 2022. It is intrinsically a modular experiment that can be naturally expanded to provide a global, sensitive all sky monitor for high-energy transients